Van Sinderen began his career in the 1980s as an art journalist and photo editor. From 1992-2001 he was curator at the Kunsthal Rotterdam, specialized in contemporary visual culture. He is a founding member and senior curator of the Hague Museum of Photography, as well as conservator of the photography collection of the Gemeentemuseum Den Haag. As a curator, Van Sinderen has produced several monographic exhibitions, ranging from historical photographers such as Erwin Blumenfeld and Manuel Alvarez Bravo to contemporary figures like Pieter Hugo and Anton Corbijn. In 2015, Wim van Sinderen was appointed member of the 2016 Deutsche Börse Photography Foundation Prize in London. He was also part of the General Jury of the 2017 World Press Photo Contest.